In this case, restoring the folder can fix your issue. The “C:\Windows\system32\config\systemprofile\Desktop is unavailable” error might happen when your Desktop folder is corrupted. If your issue still exists after the reboots, go ahead with the fix below. In this case, try restarting your computer a few times to complete the update installation. You are likely to run into the “C:\Windows\system32\config\systemprofile\Desktop is unavailable” error if the Windows update is not successfully installed on your PC. Check Desktop location through Registry Editor.You may not have to try them all just work down the list until you find the one that works for you.
If the “C:\Windows\system32\config\systemprofile\Desktop is unavailable” error occurs to you after updates, you’re not alone! Many Windows users are reporting it.
